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师资队伍
钟 超
职务/职称:副教授
研 究 所:药剂研究所
联系电话:
电子邮件:zhongc@lzu.edu.cn
办 公 室:
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】

    2023.09-至今    兰州大学澳门新葡萄新京app官网,副教授

    2021.06-2023.05  华东理工大学,材料科学与工程流动站,博士后

    2016.09-2021.06  兰州大学,基础医学,博士

    2012.09-2016.06  兰州大学,药学,学士

    【研究方向】

    1.多肽新药创制

    2.多肽及其模拟物在医用生物材料中的应用研究

    【主讲课程】

    【获奖情况】

    2020年博士研究生国家奖学金


  • 代表性论文:

    1.Zhong C#, Wu Y#, Lin H*, Liu R*. Advances in the Antimicrobial Treatment of Osteomyelitis. Composites Part B: Engineering. 2022, 249, 110428. (#Equal contribution).

    2.Zhong C, Zhang F, Yao J, Zhu Y, Zhu N, Zhang J, Ouyang X, Zhang T, Li B, Xie J, Ni J*. New Antimicrobial Peptides with Repeating Unit against Multidrug-Resistant Bacteria. ACS infectious diseases. 2021, 7(6), 1619-1637.

    3.Zhong C, Zhang F, Yao J, Zhu Y, Zhu N, Zhang Y, Liu H, Gou S, Ni J*. Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance. Biochemical pharmacology. 2021, 186, 114470.

    4.Zhong C, Zhang F, Zhu N, Zhu Y, Yao J, Gou S, Xie J, Ni J*, Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. European journal of medicinal chemistry. 2021, 212, 113138.

    5.Zhong C, Zhu Y, Zhu N, Liu T, Gou S, Zhang F, Yao J, Xie J, Ni J*. Synthesis and anti-pseudomonal activity of new β-Ala modified analogues of the antimicrobial peptide anoplin. International journal of medical microbiology. 2020, 310(5), 151433.

    6.Zhong C, Gou S, Liu T, Zhu Y, Zhu N, Liu H, Zhang Y, Xie J, Guo X, Jingman Ni*. Study on the effects of different dimerization positions on biological activity of partial d-Amino acid substitution analogues of Anoplin. Microbial pathogenesis. 2020, 139, 103871.

    7.Zhong C, Zhu N, Zhu Y, Liu T, Gou S, Xie J, Yao J, Ni J*, Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria. European journal of Pharmaceutical Sciences.2020, 141, 105123. (High cited papers).

    8.Zhong C, Liu T, Gou S, He Y, Zhu N, Zhu Y, Wang L, Liu H, Zhang Y, Yao J, Ni J*. Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. European journal of medicinal chemistry. 2019, 182, 111636.

    9.Zhang F, Yang P, Mao W, Zhong C, Zhang J, Chang L, Wu X, Liu H, Zhang Y, Gou S, Ni J*. Short, mirror-symmetric antimicrobial peptides centered on "RRR" have broad-spectrum antibacterial activity with low drug resistance and toxicity. Acta biomaterialia. 2022, 154:145-167.

    10.Wu Y, Jiang W, Cong Z, Chen K, She Y, Zhong C, Zhang W, Chen M, Zhou M, Shao N, Xiao X, Shao X, Dai Y, Fei J, Song G, Liu R*. An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections. Journal of medicinal chemistry. 2022, 65 (10), 7296-7311.

    11.Zhang F, Zhong C, Yao J, Zhang J, Zhang T, Li B, Gou S, Ni J*. Antimicrobial peptides–antibiotics combination: An effective strategy targeting drug‐resistant Gram‐negative bacteria. Peptide Science. 2022, 114(4).

    12.Gou S, Li B, Ouyang X, Ba Z, Zhong C, Ni J*. Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. ACS omega. 2021, 6(33), 21359-21367.

    13.Gou S, Li B, Ouyang X, Ba Z, Zhong C, Zhang T, Chang L, Zhu Y, Zhang J, Zhu N, Zhang Y, Liu H, Ni J*. Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. Journal of medicinal chemistry. 2021, 64 (15), 11247-11266.

    14.Chang L, Bao H, Yao J, Liu H, Gou S, Zhong C, Zhang Y, Ni J*. New designed pH-responsive histidine-rich peptides with antitumor activity. Journal of drug targeting. 2021, 29(6), 651-659.

    15.Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J*. Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. European journal of pharmaceutical sciences. 2021, 158, 105665.

    16.Gou S, Wang L, Zhong C, Chen X, Ouyang X, Li B, Bao G, Liu H, Zhang Y, Ni J*. A novel apoA-I mimetic peptide suppresses atherosclerosis by promoting physiological HDL function in apoE(-/-) mice. British journal of pharmacology. 2020, 177(20), 4627-4644.

    17.Liu T, Zhu N, Zhong C, Zhu Y, Gou S, Chang L, Bao H, Liu H, Zhang Y, Ni J*, Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin. European journal of pharmaceutical sciences. 2020, 152, 105453.

    18.Gou S, Liu B, Han X, Wang L, Zhong C, Liang S, Liu H, Qiang Y, Zhang Y, Ni*. Anti-atherosclerotic effect of Fermentum Rubrum and Gynostemma pentaphyllum mixture in high-fat emulsion- and vitamin D3-induced atherosclerotic rats. J Chin Med Assoc. 2018, 81(5), 398-408.

    19.Liu B, Huang H, Yang Z, Liu B, Gou S, Zhong C, Han X, Zhang Y, Ni J*, Wang R*. Design of novel antimicrobial peptide dimer analogues with enhanced antimicrobial activity in vitro and in vivo by intermolecular triazole bridge strategy. Peptides. 2017, 88, 115-125.

    20.Liu B, Zhang W, Gou S, Huang H, Yao J, Yang Z, Liu H, Zhong C, Liu B, N Ji*, Wang R*. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. Journal of peptide science. 2017, 23(11), 824-832.


  • 1.中国博士后科学基金第71批面上资助(202207159),主持;

    2.国家自然科学基金面上项目(81773564),2018.01-2021.12,参与;

    3.国家自然科学基金地区科学基金项目(32160230),2022.01-2025.12,参与。


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