Research Interests
1) Synthesis and modification of unnatural amino acids and polypeptides.
2) Design and synthesis molecules that exhibit sought-after function in diverse areas such as biology and material science.
Selected Publications:
1.R. Qi#, Q. Chen#, L. Liu, Z. Ma, D. Pan, H. Wang, Z. Li, C. Wang*, Z. Xu*, Copper-catalyzed asymmetric C(sp3)-H cyanoalkylation of glycine derivatives and peptides. Nat. Commun. 2023, 14, 3295.
2.R. Qi, C. Wang*, Z. Ma, H. Wang, Q. Chen, L. Liu, D. Pan, X. Ren, R. Wang*, Z. Xu*, Visible-light-promoted stereoselective C(sp3)-H glycosylation for the synthesis of C-glycoamino acids and C-glycopeptides. Angew. Chem. Int. Ed. 2022, 61, e202200822.
3.X. Zhang#, Q. Chen#, R. Song#, J. Xu, W. Tian*, S. Li, Z. Jin, Y. R. Chi*, Carbene-catalyzed α,γ-deuteration of enals under oxidative conditions. ACS Catalysis, 2020, 10, 5475.
4.Y. Liu, Q. Chen, C. Mou, L. Pan*, X. Duan, X. Chen, H. Chen, Y. Zhao, Y. Lu, Z. Jin, Y. R. Chi*, Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs. Nat. Commun. 2019, 10, 1675.
5.Q. Chen#, T. Zhu#, P. K. Majhi, C. Mou, H. Chai, J. Zhang, S. Zhuo, Y. R. Chi*, Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes. Chem. Sci. 2018, 9, 8711.
6.Q. Chen#, Y. Lei#, Y. Wang, C. Wang, Y. Wang, Z. Xu*, H. Wang, R. Wang*, Direct thiocyanation of ketene dithioacetals under transition-metal-free conditions. Org. Chem. Front. 2017, 4, 369.
7.Q. Chen#, C. Wang#, J. Zhou, Y. Wang, Z. Xu*, R. Wang*, CuSO4-Mediated decarboxylative difluoroacetamidation of α,β-unsaturated carboxylic acids. J. Org. Chem. 2016, 81, 2639.
8.C. Wang#, Q. Chen#, Q. Guo, H. Liu, Z. Xu*, Y. Liu, M. Wang, R. Wang*, Silver-catalyzed difluoroamidation of activated alkenes for the construction of difluorinated 3,3-disubstituted oxindoles. J. Org. Chem. 2016, 81, 5782.
